Please use this identifier to cite or link to this item:
http://hdl.handle.net/10609/98526
Title: | Análisis exploratorio multivariante para el estudio longitudinal de la distribución anormal de grasa, masa magra y/o masa ósea en individuos infectados por VIH |
Author: | Fernández Olivares, Guillermo Andrés |
Tutor: | Vegas Lozano, Esteban Perez-Alvarez, Nuria |
Others: | Sánchez-Pla, Alex |
Abstract: | HIV infection has experienced an increase in its prevalence during the last decades. HIV patients experienced physiological changes related to fat mass, lean mass and bone mass, causing a reduction in their quality of life. This situation is reflected in a rise of development of cardiovascular diseases, as well as an increase of muscular injuries and a high probability to suffer bone fractures. All of them are related to a quicker aging associated with a decrease in immunology system functionality. A good comprehension of HIV pathology allows researchers to develop solutions in order to improve the quality of life of all these patients. For this reason, the aim of this final MSc project, related to Statistical Bioinformatics, consisted on find which variables are related to the physiological changes mentioned, besides which kind of body changes experience these patients in a long term. For this aim, multivariate statistical methods such as Principal Component Analysis (PCA), Canonical Correlation Analysis (CCA) and Multifactorial Analysis (MFA) were used during the development of this project, due to their ability to illustrate in scant dimensions all the information storage in a big number of variables. R programming language was used to apply all these statistical methods. |
Keywords: | HIV body mass statistical analysis of data |
Document type: | info:eu-repo/semantics/masterThesis |
Issue Date: | Jun-2019 |
Publication license: | http://creativecommons.org/licenses/by-sa/3.0/es/ |
Appears in Collections: | Trabajos finales de carrera, trabajos de investigación, etc. |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
gfernandezolTFM0619memoria.pdf | Memoria del TFM | 1,06 MB | Adobe PDF | View/Open |
Share:
This item is licensed under a Creative Commons License