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http://hdl.handle.net/10609/129946
Title: | Búsqueda de nutracéuticos para la prevención y tratamiento del Alzheimer |
Author: | Ortega Vallbona, Rita Carmen |
Tutor: | Sanchez-Martinez, Melchor |
Others: | Maceira, Marc |
Abstract: | Alzheimer's disease is one of the most common neurodegenerative diseases in elderly people, for which there is no treatment. This work aims to find nutraceuticals that serve to prevent or treat this disease. To this end, a database of flavonols has been compiled. Flavonols are a subgroup of flavonoids (polyphenols) which occur abundantly in plant products and are associated with antioxidant and anti-inflammatory properties. On the other hand, 5-lipoxygenase (5-LOX), an enzyme that has a role in several mechanisms involved in Alzheimer's disease, has been chosen as the therapeutic target to work with, and information has been compiled on its known inhibitors. After this, a strategy like structure-based drug design has been followed. After docking flavonols and inhibitors to 5-LOX, the resulting interactions have been compared to choose those flavonols that interact with 5-LOX like inhibitors do. The hypothesis is that the more interactions a compound has in common with known inhibitors, the more likely it is to behave as an inhibitor. The 9 flavonols chosen in the interaction comparison were subjected to an ADMET analysis (Absorption, Diffusion, Metabolism, Excretion and Toxicity) to determine which would be the best treatment option. Finally, the natural flavonol kaempferol was chosen as a candidate with which to carry out future tests. |
Keywords: | structure-based virtual screening flavonols alzheimer |
Document type: | info:eu-repo/semantics/masterThesis |
Issue Date: | 5-Jan-2021 |
Publication license: | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ |
Appears in Collections: | Trabajos finales de carrera, trabajos de investigación, etc. |
Files in This Item:
File | Description | Size | Format | |
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rortegavTFM0121memoria.pdf | Memoria del TFM | 2,51 MB | Adobe PDF | View/Open |
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