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Título : | Anti-mitochondrial autoantibodies are associated with cardiomyopathy, dysphagia, and features of more severe disease in adult-onset myositis |
Autoría: | Sabbagh, Sara E. Pinal-Fernandez, Iago Casal Domínguez, Maria Albayda, Jemima Paik, Julie J. Miller, Frederick W. Rider, Lisa G. Mammen, Andrew Christopher-Stine, Lisa |
Otros: | Universitat Oberta de Catalunya (UOC) Johns Hopkins University School of Medicine National Institutes of Health |
Citación : | Sabbagh, S. E., Pinal-Fernandez, I., Casal-Dominguez, M., Albayda, J., Paik, J. J., Miller, F. W., Rider, L. G., Mammen, A. L., Christopher-Stine, L., Michelle, H., Tiniakou, E., Danoff, S. K., & Lloyd, T. (2021). Anti-mitochondrial autoantibodies are associated with cardiomyopathy, dysphagia, and features of more severe disease in adult-onset myositis. Clinical Rheumatology, 40(10), 4095-4100. https://doi.org/10.1007/S10067-021-05730-7/TABLES/3 |
Resumen : | We analyzed the prevalence of anti-mitochondrial autoantibodies (AMA) in adult- and juvenile-onset myositis longitudinal cohorts and investigated phenotypic differences in myositis patients with AMA. We screened sera from myositis patients including 619 adult- and 371 juvenile-onset dermatomyositis (DM, JDM), polymyositis (PM, JPM), inclusion body myositis (IBM), or amyopathic DM patients and from healthy controls, including 164 adults and 92 children, for AMA by ELISA. Clinical characteristics were compared between myositis patients with and without AMA. AMA were present in 5% of adult myositis patients (16 of 216 DM, 10 of 222 PM, 4 of 140 IBM, 1 of 19 amyopathic DM), 1% of juvenile myositis patients (3 of 302 JDM, 1 of 25 JPM), and 1% of both adult and juvenile healthy controls. In patients with adult-onset myositis, AMA were associated with persistent muscle weakness, Raynaud's phenomenon, dysphagia, and cardiomyopathy. Adult myositis patients with AMA may have more severe or treatment refractory disease, as they more frequently received glucocorticoids and intravenous immunoglobulin. In juvenile myositis, children with AMA often had falling episodes and dysphagia, but no other clinical features or medications were significantly associated with AMA. AMA are present in 5% of adult myositis patients and associated with cardiomyopathy, dysphagia, and other signs of severe disease. The prevalence of AMA is not increased in patients with juvenile myositis compared to age-matched healthy controls. Our data suggest that the presence of AMA in adult myositis patients should prompt screening for cardiac and swallowing involvement. |
Palabras clave : | Anti-mitochondrial autoantibodies Juvenile myositis Myositis |
DOI: | 10.1007/s10067-021-05730-7 |
Tipo de documento: | info:eu-repo/semantics/article |
Fecha de publicación : | 2-oct-2021 |
Licencia de publicación: | http://creativecommons.org/licenses/by/3.0/es/ |
Aparece en las colecciones: | Articles Articles cientÍfics |
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