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dc.contributor.authorCalvi, Alberto-
dc.contributor.authorHaider, Lukas-
dc.contributor.authorPrados Carrasco, Ferran-
dc.contributor.authorTUR, CARMEN-
dc.contributor.authorChard, Declan-
dc.contributor.authorBarkhof, Frederik-
dc.contributor.otherUniversity College London (UCL)-
dc.contributor.otherUniversidad Oberta de Catalunya (UOC)-
dc.identifier.citationCalvi, A., Haider, L., Prados, F., Tur, C., Chard, D. T. & Barkhof, F. (2022). In vivo imaging of chronic active lesions in multiple sclerosis. Multiple Sclerosis Journal, 28(5), 683-690. doi: 10.1177/1352458520958589-
dc.description.abstractNew clinical activity in multiple sclerosis (MS) is often accompanied by acute inflammation which subsides. However, there is growing evidence that a substantial proportion of lesions remain active well beyond the acute phase. Chronic active lesions are most frequently found in progressive MS and are characterised by a border of inflammation associated with iron-enriched cells, leading to ongoing tissue injury. Identifying imaging markers for chronic active lesions in vivo are thus a major research goal. We reviewed the literature on imaging of chronic active lesion in MS, focussing on ‘slowly expanding lesions’ (SELs), detected by volumetric longitudinal magnetic resonance imaging (MRI) and ‘rim-positive’ lesions, identified by susceptibility iron-sensitive MRI. Both SELs and rim-positive lesions have been found to be prognostically relevant to future disability. Little is known about the co-occurrence of rims around SELs and their inter-relationship with other emerging techniques such as dynamic contrast enhancement (DCE) and positron emission tomography (PET).en
dc.publisherMultiple Sclerosis Journalca
dc.relation.ispartofMultiple Sclerosis Journal, 2022, 28(5)-
dc.rightsCC BY 4.0-
dc.subjectmultiple sclerosisen
dc.subjectchronic active lesionsen
dc.subjectmagnetic resonance imagingen
dc.subjectpositron emission tomographyen
dc.subjectesclerosi múltipleca
dc.subjectlesions actives cròniquesca
dc.subjectimatges per resonancia magnèticaca
dc.subjecttomografia per emisió de positronsca
dc.subjectesclerosis múltiplees
dc.subjectlesiones activas crónicases
dc.subjectimagenes por resonancia magnéticaes
dc.subjecttomografía por emisión de positronesca
dc.subject.lcshmultiple sclerosisen
dc.titleIn vivo imaging of chronic active lesions in multiple sclerosisca
dc.subject.lemacesclerosi múltipleca
dc.subject.lcshesesclerosis múltiplees
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