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http://hdl.handle.net/10609/147057
Title: | Remyelination varies between and within lesions in multiple sclerosis following bexarotene |
Author: | Brown, William Prados Carrasco, Ferran Altmann, Daniel Kanber, Baris Stutters, Jonathan Cunniffe, Nick Jones, Joanne Georgieva, Zoya Needham, Edward Daruwalla, Cyrus Gandini Wheeler-Kingshott, Claudia A.M. Connick, Peter Chandran, Siddharthan Franklin, Robin MacManus, David Samson, Rebecca Coles, Alasdair Chard, Declan |
Others: | University of Cambridge University College London (UCL) University of Melbourne Universitat Oberta de Catalunya (UOC) London School of Hygiene and Tropical Medicine University of Pavia University of Edinburgh |
Citation: | Brown, J.W.L., Prados, F., Altmann, D.R., Kanber, Baris, Stutters, J., Cunniffe, N.G., Jones, J.L., Georgieva, Z., Needham, E., Daruwalla, C., Wheeler-Kingshott, C., Connick, P., Chandran, S., Franklin, R., MacManus, D., Samson, R. S., Coles, A.J. & Chard, D. T. (2022). Remyelination varies between and within lesions in multiple sclerosis following bexarotene. Annals of Clinical and Translational Neurology, 9(10), 1626-1642. doi: 10.1002/acn3.51662 |
Abstract: | In multiple sclerosis chronic demyelination is associated with axonal loss, and ultimately contributes to irreversible progressive disability. Enhancing remyelination may slow, or even reverse, disability. We recently trialled bexarotene versus placebo in 49 people with multiple sclerosis. While the primary MRI outcome was negative, there was converging neurophysiological and MRI evidence of efficacy. Multiple factors influence lesion remyelination. In this study we undertook a systematic exploratory analysis to determine whether treatment response – measured by change in magnetisation transfer ratio – is influenced by location (tissue type and proximity to CSF) or the degree of abnormality (using baseline magnetisation transfer ratio and T1 values). |
DOI: | http://doi.org/10.1002/acn3.51662 |
Document type: | info:eu-repo/semantics/article |
Version: | info:eu-repo/semantics/publishedVersion |
Issue Date: | 17-Sep-2022 |
Publication license: | https://creativecommons.org/licenses/by/4.0/ |
Appears in Collections: | Articles Articles cientÍfics |
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Ann_Clin_Transl_Neurol_2022_Brown_Remyelination_varies_between_and_within_lesions_in_multiple_sclerosis_following.pdf | 750,73 kB | Adobe PDF | View/Open |
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