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http://hdl.handle.net/10609/149244
Título : | Relationship between paramagnetic rim lesions and slowly expanding lesions in multiple sclerosis |
Autoría: | Calvi, Alberto Clarke, Margareta Prados Carrasco, Ferran Chard, Declan Ciccarelli, Olga Alberich, Manel Pareto, Deborah Rodríguez Barranco, Marta Sastre Garriga, Jaume TUR, CARMEN Rovira, Alex Barkhof, Frederik |
Citación : | Calvi, A. [Albert], Clarke, M.A. [Margareta A.], Prados, F. [Ferran], Chard, D. [Declan], Ciccarelli, O. [Olga], Alberich, M. [Manel], ... & Barkhof, F. [Frederik] (2023). Relationship between paramagnetic rim lesions and slowly expanding lesions in multiple sclerosis. Multiple Sclerosis Journal, 29(3), 352-62. doi: 10.1177/13524585221141964 |
Resumen : | Background: Magnetic resonance imaging (MRI) markers for chronic active lesions in MS include slowly expanding lesions (SELs) and paramagnetic rim lesions (PRLs). Objectives: To identify the relationship between SELs and PRLs in MS, and their association with disability. Methods: 61 people with MS (pwMS) followed retrospectively with MRI including baseline susceptibility-weighted imaging, and longitudinal T1 and T2-weighted scans. SELs were computed using deformation field maps; PRLs were visually identified. Mixed-effects models assessed differences in Expanded Disability Status Scale (EDSS) score changes between the group defined by the presence of SELs and or PRLs. Results: The median follow-up time was 3.2 years. At baseline, out of 1492 lesions, 616 were classified as SELs, and 80 as PRLs. 92% of patients had ⩾ 1 SEL, 56% had ⩾ 1 PRL, while both were found in 51%. SELs compared to non-SELs were more likely to also be PRLs (7% vs. 4%, p = 0.027). PRL counts positively correlated with SEL counts (ρ= 0.28, p = 0.03). SEL + PRL + patients had greater increases in EDSS over time (beta = 0.15/year, 95% confidence interval (0.04, 0.27), p = 0.009) than SEL+PRL-patients. Conclusion: SELs are more numerous than PRLs in pwMS. Compared with either SELs or PRLs found in isolation, their joint occurrence was associated with greater clinical progression. |
Palabras clave : | chronic active lesions paramagnetic rim lesions (PRLs) slowly expanding lesions (SELs) volumetric MRI susceptibility-weighted imaging (SWI) multiple sclerosis |
DOI: | https://doi.org/10.1177/13524585221141964 |
Tipo de documento: | info:eu-repo/semantics/article |
Versión del documento: | info:eu-repo/semantics/publishedVersion |
Fecha de publicación : | 14-dic-2022 |
Licencia de publicación: | https://creativecommons.org/licenses/by/4.0/ |
Aparece en las colecciones: | Articles Articles cientÍfics |
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