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http://hdl.handle.net/10609/149299
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DC Field | Value | Language |
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dc.contributor.author | Mena, Marisa | - |
dc.contributor.author | Frias-Gomez, Jon | - |
dc.contributor.author | Taberna , Miren | - |
dc.contributor.author | Quirós, Beatriz | - |
dc.contributor.author | Marquez, S. | - |
dc.contributor.author | Clavero, Omar | - |
dc.contributor.author | Baena, Antoni | - |
dc.contributor.author | Lloveras, Belen | - |
dc.contributor.author | Alejo, M. | - |
dc.contributor.author | León, X. | - |
dc.contributor.author | García, J. | - |
dc.contributor.author | Mesía, R. | - |
dc.contributor.author | Bermejo, O. | - |
dc.contributor.author | Bonfill Abella, Teresa | - |
dc.contributor.author | Aguila, A. | - |
dc.contributor.author | Guix, Marta | - |
dc.contributor.author | Hijano, R. | - |
dc.contributor.author | PAVÓN, MIGUEL ANGEL | - |
dc.contributor.author | Torres, M. | - |
dc.contributor.author | Tous, S. | - |
dc.contributor.author | Clèries, R. | - |
dc.contributor.author | Alemany, Laia | - |
dc.date.accessioned | 2023-12-14T10:31:06Z | - |
dc.date.available | 2023-12-14T10:31:06Z | - |
dc.date.issued | 2020-08-06 | - |
dc.identifier.citation | Mena, M. [Marisa], Frias-Gomez, J. [Jon], Taberna, M. [Miren], Quirós, B. [Belén], Marquez, S. [Sara], Clavero, O. [Omar], ... & Alemany, L. [Laia]. (2020). Epidemiology of human papillomavirus-related oropharyngeal cancer in a classically low-burden region of southern Europe. Scientific Reports, 10(1), 13219. doi: 10.1038/s41598-020-70118-7 | - |
dc.identifier.issn | 2045-2322MIAR | - |
dc.identifier.uri | http://hdl.handle.net/10609/149299 | - |
dc.description.abstract | The incidence of human papillomavirus (HPV)-related oropharyngeal cancer is increasing in some regions. Nevertheless, the epidemiology of this disease has not been extensively investigated in southern Europe. We conducted a retrospective cohort study of patients diagnosed with primary oropharyngeal cancer from 1991 to 2016. Cancer tissues underwent histopathological evaluation, DNA quality control, HPV-DNA detection and p16INK4a immunohistochemistry. Data were collected from medical records. Factors associated with HPV positivity and time trends were evaluated with multivariable Bayesian models. The adjusted prevalence of HPV-related cases in 864 patients with a valid HPV-DNA result was 9.7%, with HPV-DNA/p16INK4a double positivity being considered. HPV-related oropharyngeal cancer was likely to occur in non-smokers and non-drinkers, to be located in the tonsil or diagnosed at advanced stages. Time-trend analysis showed an increasing risk of HPV-related oropharyngeal cancer in the most recent periods (5-year period increase of 30%). This increase was highest and with a clear increasing trend only in the most recent years (2012–2016). The prevalence of HPV-related oropharyngeal cancer started to sharply increase in the most recent years in our setting, as occurred two decades ago in areas where most oropharyngeal cancer cases are currently HPV-related. Our results provide a comprehensive assessment of the epidemiological landscape of HPV-related oropharyngeal cancer in a region of southern Europe. | en |
dc.format.mimetype | application/pdf | ca |
dc.language.iso | eng | ca |
dc.publisher | Nature Research | ca |
dc.relation.ispartof | Scientific Reports, 2020, 10(1) | en |
dc.relation.uri | https://www.nature.com/articles/s41598-020-70118-7#further-reading | - |
dc.rights | CC BY | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | - |
dc.title | Epidemiology of human papillomavirus-related oropharyngeal cancer in a classically low-burden region of southern Europe | en |
dc.type | info:eu-repo/semantics/article | ca |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.doi | https://doi.org/10.1038/s41598-020-70118-7 | - |
dc.relation.projectID | info:eu-repo/grantAgreement/ERDF/PI1102096 | - |
dc.relation.projectID | info:eu-repo/grantAgreement/ERDF/PI1401918 | - |
dc.relation.projectID | info:eu-repo/grantAgreement/ERDF/PI1500500 | - |
dc.relation.projectID | info:eu-repo/grantAgreement/ERDF/PI1501205 | - |
dc.relation.projectID | info:eu-repo/grantAgreement/AGAUR/SGR/2017SGR1085 | - |
dc.relation.projectID | info:eu-repo/grantAgreement/CIBERESP/CB06/02/0073 | - |
dc.relation.projectID | info:eu-repo/grantAgreement/CIBERONC/CB16/12/0040 | - |
dc.relation.projectID | info:eu-repo/grantAgreement/PERIS/SLT002/16/00404 | - |
dc.relation.projectID | info:eu-repo/grantAgreement/PERIS/SLT006/17/76 | - |
dc.type.version | info:eu-repo/semantics/publishedVersion | - |
Appears in Collections: | Articles Articles cientÍfics |
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Mena_sr_Epidemiology.pdf | 1,02 MB | Adobe PDF | ![]() View/Open |
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