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http://hdl.handle.net/10609/149299
Title: | Epidemiology of human papillomavirus-related oropharyngeal cancer in a classically low-burden region of southern Europe |
Author: | Mena, Marisa ![]() Frias-Gomez, Jon ![]() Taberna , Miren ![]() Quirós, Beatriz ![]() Marquez, S. Clavero, Omar ![]() Baena, Antoni ![]() Lloveras, Belen ![]() Alejo, M. León, X. García, J. Mesía, R. Bermejo, O. Bonfill Abella, Teresa ![]() Aguila, A. Guix, Marta ![]() Hijano, R. PAVÓN, MIGUEL ANGEL ![]() Torres, M. Tous, S. Clèries, R. Alemany, Laia ![]() |
Citation: | Mena, M. [Marisa], Frias-Gomez, J. [Jon], Taberna, M. [Miren], Quirós, B. [Belén], Marquez, S. [Sara], Clavero, O. [Omar], ... & Alemany, L. [Laia]. (2020). Epidemiology of human papillomavirus-related oropharyngeal cancer in a classically low-burden region of southern Europe. Scientific Reports, 10(1), 13219. doi: 10.1038/s41598-020-70118-7 |
Abstract: | The incidence of human papillomavirus (HPV)-related oropharyngeal cancer is increasing in some regions. Nevertheless, the epidemiology of this disease has not been extensively investigated in southern Europe. We conducted a retrospective cohort study of patients diagnosed with primary oropharyngeal cancer from 1991 to 2016. Cancer tissues underwent histopathological evaluation, DNA quality control, HPV-DNA detection and p16INK4a immunohistochemistry. Data were collected from medical records. Factors associated with HPV positivity and time trends were evaluated with multivariable Bayesian models. The adjusted prevalence of HPV-related cases in 864 patients with a valid HPV-DNA result was 9.7%, with HPV-DNA/p16INK4a double positivity being considered. HPV-related oropharyngeal cancer was likely to occur in non-smokers and non-drinkers, to be located in the tonsil or diagnosed at advanced stages. Time-trend analysis showed an increasing risk of HPV-related oropharyngeal cancer in the most recent periods (5-year period increase of 30%). This increase was highest and with a clear increasing trend only in the most recent years (2012–2016). The prevalence of HPV-related oropharyngeal cancer started to sharply increase in the most recent years in our setting, as occurred two decades ago in areas where most oropharyngeal cancer cases are currently HPV-related. Our results provide a comprehensive assessment of the epidemiological landscape of HPV-related oropharyngeal cancer in a region of southern Europe. |
DOI: | https://doi.org/10.1038/s41598-020-70118-7 |
Document type: | info:eu-repo/semantics/article |
Version: | info:eu-repo/semantics/publishedVersion |
Issue Date: | 6-Aug-2020 |
Publication license: | http://creativecommons.org/licenses/by/3.0/es/ ![]() |
Appears in Collections: | Articles Articles cientÍfics |
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File | Description | Size | Format | |
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Mena_sr_Epidemiology.pdf | 1,02 MB | Adobe PDF | ![]() View/Open |
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