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DC Field | Value | Language |
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dc.contributor.author | Chiva-Blanch, Gemma | - |
dc.contributor.author | urpi, mireia | - |
dc.contributor.author | llorach, rafael | - |
dc.contributor.author | Rotches-Ribalta, Maria | - |
dc.contributor.author | Guillén, Marisa | - |
dc.contributor.author | Casas, Rosa | - |
dc.contributor.author | Arranz, Sara | - |
dc.contributor.author | Valderas-Martínez, Palmira | - |
dc.contributor.author | Portoles, Olga | - |
dc.contributor.author | Dolores, Corella | - |
dc.contributor.author | Tinahones, Francisco J | - |
dc.contributor.author | Lamuela-Raventos, Rosa M | - |
dc.contributor.author | Andres-Lacueva, Cristina | - |
dc.contributor.author | Estruch Riba, Ramón | - |
dc.date.accessioned | 2024-01-17T09:29:00Z | - |
dc.date.available | 2024-01-17T09:29:00Z | - |
dc.date.issued | 2012-02 | - |
dc.identifier.citation | Chiva-Blanch, G. [Gemma], Urpi-Sarda, M. [Mireia], Llorach, R. [Rafael], Rotches-Ribalta, M. [Maria], Guillén, M. [Marisa], Casas, R. [Rosa], ... & Estruch, R. [Ramon]. (2012). Differential effects of polyphenols and alcohol of red wine on the expression of adhesion molecules and inflammatory cytokines related to atherosclerosis: a randomized clinical trial. The American Journal of Clinical Nutrition, 95(2), 326-34. doi: 10.3945/ajcn.111.022889 | - |
dc.identifier.issn | 0002-9165MIAR | - |
dc.identifier.uri | http://hdl.handle.net/10609/149398 | - |
dc.description.abstract | Background: Few clinical studies have focused on the alcohol-independent cardiovascular effects of the phenolic compounds of red wine (RW). Objective: We aimed to evaluate the effects of ethanol and phenolic compounds of RW on the expression of inflammatory biomarkers related to atherosclerosis in subjects at high risk of cardiovascular disease. Design: Sixty-seven high-risk, male volunteers were included in a randomized, crossover consumption trial. After a washout period, all subjects received RW (30 g alcohol/d), the equivalent amount of dealcoholized red wine (DRW), or gin (30 g alcohol/d) for 4 wk. Before and after each intervention period, 7 cellular and 18 serum inflammatory biomarkers were evaluated. Results: Alcohol increased IL-10 and decreased macrophage-derived chemokine concentrations, whereas the phenolic compounds of RW decreased serum concentrations of intercellular adhesion molecule-1, E-selectin, and IL-6 and inhibited the expression of lymphocyte function-associated antigen 1 in T lymphocytes and macrophage-1 receptor, Sialil-Lewis X, and C-C chemokine receptor type 2 expression in monocytes. Both ethanol and phenolic compounds of RW downregulated serum concentrations of CD40 antigen, CD40 ligand, IL-16, monocyte chemotactic protein-1, and vascular cell adhesion molecule-1. Conclusion: The results suggest that the phenolic content of RW may modulate leukocyte adhesion molecules, whereas both ethanol and polyphenols of RW may modulate soluble inflammatory mediators in high-risk patients. The trial was registered in the International Standard Randomized Controlled Trial Number Register at http://www.isrctn.org/ as ISRCTN88720134. | en |
dc.format.mimetype | application/pdf | ca |
dc.language.iso | eng | ca |
dc.publisher | Elsevier | ca |
dc.relation.ispartof | The American Journal of Clinical Nutrition, 95(2) | ca |
dc.relation.uri | https://www.sciencedirect.com/science/article/pii/S0002916523026618#aep-article-footnote-id1 | - |
dc.rights | CC BY-NC-ND | - |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ | - |
dc.title | Differential effects of polyphenols and alcohol of red wine on the expression of adhesion molecules and inflammatory cytokines related to atherosclerosis: a randomized clinical trial | ca |
dc.type | info:eu-repo/semantics/article | ca |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.doi | https://doi.org/10.3945/ajcn.111.022889 | - |
dc.type.version | info:eu-repo/semantics/publishedVersion | - |
Appears in Collections: | Articles Articles cientÍfics |
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Chiva_tajcn_Differential.pdf | 110,21 kB | Adobe PDF | View/Open |
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