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http://hdl.handle.net/10609/149398
Title: | Differential effects of polyphenols and alcohol of red wine on the expression of adhesion molecules and inflammatory cytokines related to atherosclerosis: a randomized clinical trial |
Author: | Chiva-Blanch, Gemma urpi, mireia llorach, rafael Rotches-Ribalta, Maria Guillén, Marisa Casas, Rosa Arranz, Sara Valderas-Martínez, Palmira Portoles, Olga Dolores, Corella Tinahones, Francisco J Lamuela-Raventos, Rosa M Andres-Lacueva, Cristina Estruch Riba, Ramón |
Citation: | Chiva-Blanch, G. [Gemma], Urpi-Sarda, M. [Mireia], Llorach, R. [Rafael], Rotches-Ribalta, M. [Maria], Guillén, M. [Marisa], Casas, R. [Rosa], ... & Estruch, R. [Ramon]. (2012). Differential effects of polyphenols and alcohol of red wine on the expression of adhesion molecules and inflammatory cytokines related to atherosclerosis: a randomized clinical trial. The American Journal of Clinical Nutrition, 95(2), 326-34. doi: 10.3945/ajcn.111.022889 |
Abstract: | Background: Few clinical studies have focused on the alcohol-independent cardiovascular effects of the phenolic compounds of red wine (RW). Objective: We aimed to evaluate the effects of ethanol and phenolic compounds of RW on the expression of inflammatory biomarkers related to atherosclerosis in subjects at high risk of cardiovascular disease. Design: Sixty-seven high-risk, male volunteers were included in a randomized, crossover consumption trial. After a washout period, all subjects received RW (30 g alcohol/d), the equivalent amount of dealcoholized red wine (DRW), or gin (30 g alcohol/d) for 4 wk. Before and after each intervention period, 7 cellular and 18 serum inflammatory biomarkers were evaluated. Results: Alcohol increased IL-10 and decreased macrophage-derived chemokine concentrations, whereas the phenolic compounds of RW decreased serum concentrations of intercellular adhesion molecule-1, E-selectin, and IL-6 and inhibited the expression of lymphocyte function-associated antigen 1 in T lymphocytes and macrophage-1 receptor, Sialil-Lewis X, and C-C chemokine receptor type 2 expression in monocytes. Both ethanol and phenolic compounds of RW downregulated serum concentrations of CD40 antigen, CD40 ligand, IL-16, monocyte chemotactic protein-1, and vascular cell adhesion molecule-1. Conclusion: The results suggest that the phenolic content of RW may modulate leukocyte adhesion molecules, whereas both ethanol and polyphenols of RW may modulate soluble inflammatory mediators in high-risk patients. The trial was registered in the International Standard Randomized Controlled Trial Number Register at http://www.isrctn.org/ as ISRCTN88720134. |
DOI: | https://doi.org/10.3945/ajcn.111.022889 |
Document type: | info:eu-repo/semantics/article |
Version: | info:eu-repo/semantics/publishedVersion |
Issue Date: | Feb-2012 |
Publication license: | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ |
Appears in Collections: | Articles Articles cientÍfics |
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Chiva_tajcn_Differential.pdf | 110,21 kB | Adobe PDF | View/Open |
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