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Título : | Virgin olive oil and nuts as key foods of the Mediterranean diet effects on inflammatory biomarkers related to atherosclerosis |
Autoría: | urpi, mireia Casas, Rosa Chiva-Blanch, Gemma Romero-Mamani, Edwin Saúl Valderas-Martínez, Palmira Arranz, Sara Andres-Lacueva, Cristina llorach, rafael Medina-Remón, Alexander Lamuela-Raventos, Rosa M Estruch Riba, Ramón |
Citación : | Urpi-Sarda, M. [Mireia], Casas, R. [Rosa], Chiva-Blanch, G. [Gemma], Romero-Mamani, E. S. [Edwin Saúl], Valderas-Martínez, P. [Palmira], Arranz, S. [Sara], ... & Estruch, R. [Ramon] (2012). Virgin olive oil and nuts as key foods of the Mediterranean diet effects on inflammatory biomarkers related to atherosclerosis. Pharmacological research, 65(6), 577-583. |
Resumen : | Previous epidemiological and feeding studies have observed that adherence to Mediterranean diet (Med-Diet) is associated with reduced cardiovascular risk. However, the molecular mechanisms involved are not fully understood. Since atherosclerosis is nowadays considered a low-grade inflammatory disease, recent studies have explored the anti-inflammatory effects of a Med-Diet intervention on serum and cellular biomarkers related to atherosclerosis. In two sub-studies of the PREDIMED (PREvencion con DIeta MEDiterranea) trial, we analyzed the effects at 3 months of two Med-Diet interventions supplemented with either virgin olive oil (VOO) or nuts compared with a control low-fat diet (LFD). Both Med-Diets showed an anti-inflammatory effect reducing serum C-reactive protein, interleukin-6 (IL6) and endothelial and monocytary adhesion molecules and chemokines (P < 0.05; all), whereas these parameters increased after the LFD intervention (P < 0.05; all). In another substudy, we evaluated the long-term (1 year) effects of these interventions on vascular risk factors in 516 high-risk subjects, as well as the effect of different Med-Diet components in the reduction of these biomarkers. At 1 year, the Med-Diet groups had significant decreases in the plasma concentrations of IL6, tumor necrosis factor receptor (TNFR) 60 and TNFR80 (P < 0.05), while intercellular adhesion molecule 1 (ICAM-1), TNFR60 and TNFR80 concentrations increased in the LFD group (P < 0.002). In addition, those allocated in the highest tertile of VOO and vegetables consumption had a significant diminution of plasma TNFR60 concentration compared with those in tertile 1 (P < 0.02). In conclusion, Med-Diet exerts an anti-inflammatory effect on cardiovascular system since it down-regulates cellular and circulating inflammatory biomarkers related to atherogenesis in subjects at high cardiovascular risk. |
DOI: | https://doi.org/10.1016/j.phrs.2012.03.006 |
Tipo de documento: | info:eu-repo/semantics/article |
Versión del documento: | info:eu-repo/semantics/acceptedVersion |
Fecha de publicación : | 2-jun-2012 |
Licencia de publicación: | http://creativecommons.org/licenses/by-nc-nd/4.0/ |
Aparece en las colecciones: | Articles Articles cientÍfics |
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Urpi_PharmacologicalResearch_Virgin.pdf | 814,57 kB | Adobe PDF | Visualizar/Abrir |
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