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http://hdl.handle.net/10609/150629
Título : | Sun and ski holidays improve vitamin D status, but are associated with high levels of DNA damage |
Autoría: | Petersen, Bibi Wulf, Hans Christian Triguero-Mas, Margarita Philipsen, Peter Alshede Thieden, Elisabeth Olsen, Peter Heydenreich, Jakob Dadvand, Payam Basagaña, Xavier Liljendahl, Tove S. Harrison, Graham I. Segerbäck, Dan Schmalwieser, Alois W. Young , Antony R. Nieuwenhuijsen, Mark |
Citación : | Petersen, B. [Bibi], Wulf, H. C. [Hans C.], Triguero-Mas, M. [Margarita], Philipsen, P. A. [Peter A.], Thieden, E. [Elisabeth], Olsen, P. [Peter], ... & Nieuwenhuijsen, M. J. [Mark J.] (2014). Sun and ski holidays improve vitamin D status, but are associated with high levels of DNA damage. Journal of Investigative Dermatology, 134(11), 2806-2813. |
Resumen : | Skin cancer is caused by solar UVR, which is also essential for vitamin D production. DNA damage (thymine dimers: T-T dimers) and vitamin D (25(OH)D) synthesis are both initiated by solar UVB. We aimed to investigate the simultaneous adverse and beneficial effects of solar UVB exposure in holidaymakers. Sun-seekers and skiers (n=71) were observed over 6 days through on-site monitoring, personal diary entries, and recording of personal UVB exposure doses with electronic dosimeters. Urine and blood samples were analyzed for T-T dimers and 25(OH)D, respectively. The volunteers had a statistically significant increase in vitamin D. There were strong associations between UVB exposure and post-holiday levels of T-T dimers and vitamin D, as well as between post-holiday T-T dimers and vitamin D. We conclude that UVB-induced vitamin D synthesis is associated with considerable DNA damage in the skin. These data, on two major health predictors, provide a basis for further field studies that may result in better understanding of the risks and benefits of “real life” solar exposure. However, vitamin D status can be improved more safely through the use of vitamin D dietary supplements. |
DOI: | https://doi.org/10.1038/jid.2014.223 |
Tipo de documento: | info:eu-repo/semantics/article |
Versión del documento: | info:eu-repo/semantics/acceptedVersion |
Fecha de publicación : | 2-nov-2014 |
Licencia de publicación: | http://creativecommons.org/licenses/by-nc-nd/4.0/es/ |
Aparece en las colecciones: | Articles Articles cientÍfics |
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Petersen_JID_Sun.pdf | 874,42 kB | Adobe PDF | Visualizar/Abrir |
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