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Title: HIV-1 subtype B molecular evolution across antiretroviral regimens
Author: Domínguez Rodríguez, Sara
Director: Sánchez Martínez, Melchor
Tutor: Marco Galindo, Maria Jesús
Others: Universitat Oberta de Catalunya
Keywords: HIV
molecular evolution
Issue Date: Jan-2017
Publisher: Universitat Oberta de Catalunya
Abstract: In this paper we intend to know the evolution of the HIV-1 virus in the most common first-line regimens. For this study, 46 patients with available RT sequence were treated primarily with one of the two regimens (Group 1: 2ITIAN + 1IP vs. Group 2: 2ITIAN + 1ITINAN). Phylogenetic trees were constructed using Bayesian approximations and maximum likelihood. The temporal relationship between treatment time and diversity was analyzed and genetic diversity was compared in both groups as a proxy for evolution velocity. Selection pressure was measured by the difference between non-synonymous and synonymous mutations.
Language: Spanish
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