Please use this identifier to cite or link to this item:
http://hdl.handle.net/10609/60667
Title: | HIV-1 subtype B molecular evolution across antiretroviral regimens |
Author: | Domínguez Rodríguez, Sara |
Tutor: | Sanchez-Martinez, Melchor |
Others: | Universitat Oberta de Catalunya Marco-Galindo, Maria-Jesús |
Abstract: | In this paper we intend to know the evolution of the HIV-1 virus in the most common first-line regimens. For this study, 46 patients with available RT sequence were treated primarily with one of the two regimens (Group 1: 2ITIAN + 1IP vs. Group 2: 2ITIAN + 1ITINAN). Phylogenetic trees were constructed using Bayesian approximations and maximum likelihood. The temporal relationship between treatment time and diversity was analyzed and genetic diversity was compared in both groups as a proxy for evolution velocity. Selection pressure was measured by the difference between non-synonymous and synonymous mutations. |
Keywords: | HIV molecular evolution phylogenetics |
Document type: | info:eu-repo/semantics/masterThesis |
Issue Date: | Jan-2017 |
Publication license: | http://www.gnu.org/licenses/gpl.html |
Appears in Collections: | Trabajos finales de carrera, trabajos de investigación, etc. |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
sdominguezrodTFM0117memoria.pdf | memoria | 1,56 MB | Adobe PDF | View/Open |
Share:
Items in repository are protected by copyright, with all rights reserved, unless otherwise indicated.