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http://hdl.handle.net/10609/92408
Title: | A chiral probe for the acute phase proteins alpha-1-acid glycoprotein and alpha-1-antitrypsin based on europium luminescence |
Author: | Carr, Rachel Di Bari, Lorenzo Lo Piano, Samuele Parker, David Peacock, Robert D. Sanderson, John M. |
Citation: | Carr, R., Di Bari, L., Lo Piano, S., Parker, D., Peacock, R. D. & Sanderson, J. M. (2012). A chiral probe for the acute phase proteins alpha-1-acid glycoprotein and alpha-1-antitrypsin based on europium luminescence. Dalton Transactions, 41(), 3154-13158. doi:10.1039/c2dt30143a |
Abstract: | Reversible and selective binding of a dynamically racemic europium(III) complex to alpha-1-acid glycoprotein and alpha-1-antitrypsin is characterised by a significant change in the europium total emission spectral fingerprint and the switching on of a large circularly polarised luminescence (CPL) signal from the metal centre. Observation of an induced CD into the ligand chromophore in the presence of alpha-1-AGP allows a structure for the protein-bound complex to be postulated. A direct determination of elevated alpha-1-AGP levels in human serum was achieved by monitoring changes in the intensity ratio of Eu emission bands. |
Keywords: | luminescence europium |
DOI: | 10.1039/c2dt30143a |
Document type: | info:eu-repo/semantics/article |
Issue Date: | 13-Feb-2012 |
Appears in Collections: | Articles cientÍfics |
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