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Título : Transcranial magnetic stimulation intervention in Alzheimer's disease: A research proposal for a randomized controlled trial NCT03121066 NCT
Autoría: Muñoz Marrón, Elena
Viejo-Sobera, Raquel  
Quintana, María
Redolar-Ripoll, Diego  
Rodríguez, Daniel
Garolera, Maite  
Otros: Consorci Sanitari de Terrassa
Universitat Oberta de Catalunya. Estudis de Ciències de la Salut
Citación : Muñoz Marrón, E., Viejo-Sobera, R., Quintana, M., Redolar Ripoll, D., Rodríguez, D. & Garolera, M. (2018). Transcranial magnetic stimulation intervention in Alzheimer's disease: A research proposal for a randomized controlled trial NCT03121066 NCT. BMC Research Notes, 11(1), 1-8. doi: 10.1186/s13104-018-3757-z
Resumen : Alzheimer's disease is a major health problem in our society. To date, pharmacological treatments have obtained poor results and there is a growing interest in finding non-pharmacological interventions for this disease. Transcranial magnetic stimulation (TMS) is a non-invasive technique that is able to induce changes in brain activity and long-term modifications in impaired neural networks, becoming a promising clinical intervention. Our goal is to study the benefit of individualized TMS targeting based on the patient's functional connectivity (personalized targeting), and short duration TMS protocol, instead of current non-individualized and longer session approaches. A double blind randomized controlled trial will be conducted to assess the effects of TMS treatment immediately, 1 month, 3 months and 6 months after the end of the intervention. Fifty-four patients with a diagnosis of Alzheimer's disease will be randomly allocated into experimental (active TMS), sham control, or conventional intervention control group. We will quantify changes in cognitive, functional, and emotional deficits in Alzheimer patients, as well as the functional connectivity changes induced by the TMS treatment. Results, we expect to demonstrate that personalized TMS intervention has a measurable positive impact in cognition, emotion, daily living activities and brain connectivity, thus representing a potential treatment for Alzheimer's disease. Trial registration The trial has been prospectively registered at ClinicalTrials.gov, identifier NCT03121066.
Palabras clave : TMS
estimulación de ráfagas theta
córtex parietal
estimulación cerebral no invasiva
corteza prefrontal dorsolateral
conectividad funcional
enfermedad de Alzheimer
DOI: 10.1186/s13104-018-3757-z
Tipo de documento: info:eu-repo/semantics/article
Versión del documento: info:eu-repo/semantics/publishedVersion
Fecha de publicación : 5-sep-2018
Licencia de publicación: http://creativecommons.org/licenses/by/3.0/es/  
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