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DC Field | Value | Language |
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dc.contributor.author | Gandini Wheeler-Kingshott, Claudia A.M. | - |
dc.contributor.author | Riemer, Frank | - |
dc.contributor.author | Palesi, Fulvia | - |
dc.contributor.author | Ricciardi, Antonio | - |
dc.contributor.author | Castellazzi, Gloria | - |
dc.contributor.author | Golay, Xavier | - |
dc.contributor.author | Prados Carrasco, Ferran | - |
dc.contributor.author | Solanky, Bhavana | - |
dc.contributor.author | D'Angelo, Egidio U. | - |
dc.contributor.other | Universitat Oberta de Catalunya (UOC) | - |
dc.contributor.other | University College London (UCL) | - |
dc.contributor.other | Università degli Studi di Pavia | - |
dc.date.accessioned | 2019-04-15T11:37:24Z | - |
dc.date.available | 2019-04-15T11:37:24Z | - |
dc.date.issued | 2018-11-09 | - |
dc.identifier.citation | Gandini Wheeler-Kinshott, C., Riemer, F., Palesi, F., Ricciardi, A., Castellazzi, G., Golay, X., Prados, F., Solanky, B. & D'Angelo, E.U. (2018). Challenges and perspectives of quantitative functional sodium imaging (fNaI). Frontiers in Neuroscience, 12(). doi:10.3389/fnins.2018.00810 | - |
dc.identifier.issn | 1662-453XMIAR | - |
dc.identifier.uri | http://hdl.handle.net/10609/93229 | - |
dc.description.abstract | Brain function has been investigated via the blood oxygenation level dependent (BOLD) effect using magnetic resonance imaging (MRI) for the past decades. Advances in sodium imaging offer the unique chance to access signal changes directly linked to sodium ions (23Na) flux across the cell membrane, which generates action potentials, hence signal transmission in the brain. During this process 23Na transiently accumulates in the intracellular space. Here we show that quantitative functional sodium imaging (fNaI) at 3T is potentially sensitive to 23Na concentration changes during finger tapping, which can be quantified in gray and white matter regions key to motor function. For the first time, we measured a 23Na concentration change of 0.54 mmol/l in the ipsilateral cerebellum, 0.46 mmol/l in the contralateral primary motor cortex (M1), 0.27 mmol/l in the corpus callosum and -11 mmol/l in the ipsilateral M1, suggesting that fNaI is sensitive to distributed functional alterations. Open issues persist on the role of the glymphatic system in maintaining 23Na homeostasis, the role of excitation and inhibition as well as volume distributions during neuronal activity. Haemodynamic and physiological signal recordings coupled to realistic models of tissue function will be critical to understand the mechanisms of such changes and contribute to meeting the overarching challenge of measuring neuronal activity in vivo. | en |
dc.language.iso | eng | - |
dc.publisher | Frontiers in Neuroscience | - |
dc.relation.ispartof | Frontiers in Neuroscience, 2018, 12() | - |
dc.relation.uri | https://www.frontiersin.org/articles/10.3389/fnins.2018.00810/pdf | - |
dc.rights | CC BY | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | - |
dc.subject | sodium imaging | en |
dc.subject | functional imaging | en |
dc.subject | neuronal activity | en |
dc.subject | BOLD contrast imaging | en |
dc.subject | MRI | en |
dc.subject | imagen funcional | es |
dc.subject | imatges funcionals | ca |
dc.subject | IRM | es |
dc.subject | IRM | ca |
dc.subject | activitat neuronal | ca |
dc.subject | actividad neuronal | es |
dc.subject | imágenes de sodio | es |
dc.subject | imatges de sodi | ca |
dc.subject | imagen de contraste dependiente del nivel de oxígeno en la sangre | es |
dc.subject | imatge de contrast depenent del nivell d'oxigen a la sang | ca |
dc.subject.lcsh | Neurochemistry | en |
dc.title | Challenges and perspectives of quantitative functional sodium imaging (fNaI) | - |
dc.type | info:eu-repo/semantics/article | - |
dc.subject.lemac | Neuroquímica | ca |
dc.subject.lcshes | Neuroquímica | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.doi | 10.3389/fnins.2018.00810 | - |
dc.gir.id | AR/0000006641 | - |
dc.type.version | info:eu-repo/semantics/publishedVersion | - |
Appears in Collections: | Articles Articles cientÍfics |
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functionalsodium.pdf | 1,42 MB | Adobe PDF | View/Open |
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