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http://hdl.handle.net/10609/105006
Title: | Generalised boundary shift integral for longitudinal assessment of spinal cord atrophy |
Author: | Prados Carrasco, Ferran Moccia, Marcello Johnson, Aubrey Yiannakas, Marios Grussu, Francesco Cardoso, Manuel Jorge Ciccarelli, Olga Ourselin, Sebastien Barkhof, Frederik Gandini Wheeler-Kingshott, Claudia A.M. |
Others: | University College London (UCL) Università degli Studi di Pavia King's College London Universitat Oberta de Catalunya (UOC) |
Citation: | Prados, F., Moccia, M., Johnson A., Yiannakas M., Grussu, F., Cardoso, M. J., Ciccarelli, O., Ourselin, S., Barkhof, F., Wheeler-Kingshott, C. (2020). Generalised boundary shift integral for longitudinal assessment of spinal cord atrophy. NeuroImage, 209. doi: 10.1016/j.neuroimage.2019.116489 |
Abstract: | Spinal cord atrophy measurements obtained from structural magnetic resonance imaging (MRI) are associated with disability in many neurological diseases and serveasin vivobiomarkers of neurodegeneration. Longitudinal spinal cord atrophy rate is commonly determined from the numerical difference between two volumes (basedon 3D surfacefitting) or two cross-sectional areas (CSA, based on 2D edge detection) obtained at different time-points. Being an indirect measure, atrophy rates aresusceptible to variable segmentation errors at the edge of the spinal cord. To overcome those limitations, we developed a new registration-based pipeline thatmeasures atrophy rates directly. We based our approach on the generalised boundary shift integral (GBSI) method, which registers 2 scans and uses a probabilistic XORmask over the edge of the spinal cord, thereby measuring atrophy more accurately than segmentation-based techniques. Using a large cohort of longitudinal spinalcord images (610 subjects with multiple sclerosis from a multi-centre trial and 52 healthy controls), we demonstrated that GBSI is a sensitive, quantitative andobjective measure of longitudinal spinal cord volume change. The GBSI pipeline is repeatable, reproducible, and provides more precise measurements of longitudinalspinal cord atrophy than segmentation-based methods in longitudinal spinal cord atrophy studies. |
Keywords: | Spinal cord atrophy GBSI Method |
DOI: | 10.1016/j.neuroimage.2019.116489 |
Document type: | info:eu-repo/semantics/article |
Version: | info:eu-repo/semantics/publishedVersion |
Issue Date: | 1-Apr-2020 |
Publication license: | http://creativecommons.org/licenses/by/4.0/es/ |
Appears in Collections: | Articles Articles cientÍfics |
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Prados_NeuroImage_Spinal_cord.pdf | 1,33 MB | Adobe PDF | View/Open |
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