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http://hdl.handle.net/10609/136820
Title: | Automated quantitative MRI volumetry reports support diagnostic interpretation in dementia: a multi-rater, clinical accuracy study |
Author: | Pemberton, Hugh ![]() Goodkin, Olivia ![]() Prados Carrasco, Ferran ![]() Das, Ravi K. Vos, Sjoerd B. Moggridge, James Coath, William Gordon, Elizabeth Barrett, Ryan Schmitt, Anne Whiteley-Jones, Hefina Burd, Christian Wattjes, Mike P. Haller, Sven Vernooij, Meike W. Harper, Lorna Fox, Nick C. Paterson, Ross W. Schott, Jonathan M. Bisdas, Sotirios ![]() White, Mark Ourselin, Sebastien Thornton, John S. Yousry, Tarek ![]() Cardoso, Manuel Jorge Barkhof, Frederik ![]() |
Others: | Universitat Oberta de Catalunya University College London (UCL) Brighton and Sussex University Hospitals Hannover Medical School Uppsala University King's College London |
Citation: | Pemberton, H.G., Goodkin, O., Prados, F. et al. Automated quantitative MRI volumetry reports support diagnostic interpretation in dementia: a multi-rater, clinical accuracy study. Eur Radiol 31, 5312-5323 (2021). https://doi.org/10.1007/s00330-020-07455-8 |
Abstract: | Objectives We examined whether providing a quantitative report (QReport) of regional brain volumes improves radiologists' accuracy and confidence in detecting volume loss, and in differentiating Alzheimer's disease (AD) and frontotemporal dementia (FTD), compared with visual assessment alone. Methods Our forced-choice multi-rater clinical accuracy study used MRI from 16 AD patients, 14 FTD patients, and 15 healthy controls; age range 52-81. Our QReport was presented to raters with regional grey matter volumes plotted as percentiles against data from a normative population (n=461). Nine raters with varying radiological experience (3 each: consultants, registrars, ¿non-clinical image analysts¿) assessed each case twice (with and without the QReport). Raters were blinded to clinical and demographic information; they classified scans as "normal" or "abnormal" and if "abnormal" as "AD" or "FTD". Results The QReport improved sensitivity for detecting volume loss and AD across all raters combined (p=0.015* and p=0.002*, respectively). Only the consultant group¿s accuracy increased significantly when using the QReport (p= 0.02*). Overall, raters' agreement (Cohen's k) with the "gold standard" was not significantly affected by the QReport; only the consultant group improved significantly (ks 0.41¿0.55, p= 0.04*). Cronbach's alpha for interrater agreement improved from 0.886 to 0.925, corresponding to an improvement from "good" to "excellent". Conclusion Our QReport referencing single-subject results to normative data alongside visual assessment improved sensitivity, accuracy, and interrater agreement for detecting volume loss. The QReport was most effective in the consultants, suggesting that experience is needed to fully benefit from the additional information provided by quantitative analyses. |
Keywords: | Alzheimer's disease Frontotemporal dementia Radiologists Magnetic resonance imaging Atrophy |
DOI: | 10.1007/s00330-020-07455-8 |
Document type: | info:eu-repo/semantics/article |
Issue Date: | 15-Jan-2021 |
Publication license: | http://creativecommons.org/licenses/by/3.0/es/ ![]() |
Appears in Collections: | Articles Articles cientÍfics |
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