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http://hdl.handle.net/10609/146723
Títol: | poly(I:C) synergizes with proteasome inhibitors to induce apoptosis in cervical cancer cells |
Autoria: | Meng, Xueqiong Cui, Xiaoxi Shao, Xiaoya Liu, Yanqi Xing, Yihao Smith, Victoria Xiong, Shiqiu Macip, Salvador Chen, Yixiang |
Altres: | Henan University of Science and Technology University of Leicester Universitat Oberta de Catalunya |
Resum: | Cervical cancer is one of the most common malignancies in women, with a poor survival rate. Thus, there is a need to define effective combination strategies to improve therapy. In this study, we report that dsRNA poly(I:C) up-regulated the expression of IFNβ and apoptosis-associated genes in cervical cancer cells, activating both intrinsic and extrinsic apoptotic pathways, and eventually inducing cell death. Similarly, proteasome inhibitors also effectively induced cervical cancer cell apoptosis, probably through prevention of p53 degradation, inhibiting NF-κB signal activation and decreasing BCL-2 expression. Importantly, the combination of poly(I:C) with proteasome inhibitors enhanced caspase-8 and caspase-9 activation, and synergistically induced cervical cancer cell apoptosis. Both activated p38 signals and increased ROS levels, and their combination extended these effects. Collectively, we show that the activation of multiple pro-apoptotic pathways by poly(I:C) and proteasome inhibitors underpin a synergistic effect on inducing cervical cancer cell death, suggesting a potential therapeutic combination with clinical relevance. |
Paraules clau: | cancer cervical poly(I.C.) inhibidor del proteasoma combinació apoptosis |
DOI: | https://doi.org/10.1016/j.tranon.2022.101362 |
Tipus de document: | info:eu-repo/semantics/article |
Versió del document: | info:eu-repo/semantics/publishedVersion |
Data de publicació: | 2-abr-2022 |
Llicència de publicació: | http://creativecommons.org/licenses/by-nc-nd/4.0 |
Apareix a les col·leccions: | Articles Articles cientÍfics |
Arxius per aquest ítem:
Arxiu | Descripció | Mida | Format | |
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1-s2.0-S1936523322000249-main.pdf | poly(I:C) synergizes with proteasome inhibitors to induce apoptosis in cervical cancer cells | 2,62 MB | Adobe PDF | Veure/Obrir |
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