Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10609/147008
Título : Acute corticospinal tract diffusion tensor imaging predicts 6-month functional outcome after intracerebral haemorrhage
Autoría: Schwarz, G.
Kanber, Baris  
Prados Carrasco, Ferran  
Browning, S.
Simister, R.
Jäger, R.
Ambler, G.
Gandini Wheeler-Kingshott, Claudia A.M.  
Werring, David J.
Otros: University College London (UCL)
Universitat Oberta de Catalunya (UOC)
Citación : Schwarz, G., Kanber, B., Prados, F., Browning, S., Simister, R., Jäger, H.R., Ambler, G., Wheeler-Kingshott, C. & Werring, D. (2022). Acute corticospinal tract diffusion tensor imaging predicts 6-month functional outcome after intracerebral haemorrhage. Journal of Neurology, 1-9. doi: 10.1007/s00415-022-11245-1
Resumen : Introduction: Diffusion tensor imaging (DTI) can assess the structural integrity of the corticospinal tract (CST) in vivo. We aimed to investigate whether CST DTI metrics after intracerebral haemorrhage (ICH) are associated with 6-month functional outcome and can improve the predictive performance of the existing ICH score. Methods: We retrospectively included 42 patients with DTI performed within 5 days after deep supratentorial spontaneous ICH. Ipsilesional-to-contralesional ratios were calculated for fractional anisotropy (rFA) and mean diffusivity (rMD) in the pontine segment (PS) of the CST. We determined the most predictive variables for poor 6-month functional outcome [modified Rankin Scale (mRS) > 2] using the least absolute shrinkage and selection operator (LASSO) method. We calculated discrimination using optimism-adjusted estimation of the area under the curve (AUC). Results: Patients with 6-month mRS > 2 had lower rFA (0.945 [± 0.139] vs 1.045 [± 0.130]; OR 0.004 [95% CI 0.00–0.77]; p =  0.04) and higher rMD (1.233 [± 0.418] vs 0.963 [± 0.211]; OR 22.5 [95% CI 1.46–519.68]; p = 0.02). Discrimination (AUC) values were: 0.76 (95% CI 0.61–0.91) for the ICH score, 0.71 (95% CI 0.54–0.89) for rFA, and 0.72 (95% CI 0.61–0.91) for rMD. Combined models with DTI and non-DTI variables offer an improvement in discrimination: for the best model, the AUC was 0.82 ([95% CI 0.68–0.95]; p = 0.15). Conclusion: In our exploratory study, PS-CST rFA and rMD had comparable predictive ability to the ICH score for 6-month functional outcome. Adding DTI metrics to clinical-radiological scores might improve discrimination, but this needs to be investigated in larger studies.
Palabras clave : hemorragia intracerebral profunda
predicción de resultados
anisotropía fraccionada
difusión media
puntaje ICH
tracto corticoespinal
DOI: https://doi.org/10.1007/s00415-022-11245-1
Tipo de documento: info:eu-repo/semantics/article
Versión del documento: info:eu-repo/semantics/publishedVersion
Fecha de publicación : 21-jul-2022
Licencia de publicación: https://creativecommons.org/licenses/by/4.0/  
Aparece en las colecciones: Articles cientÍfics
Articles

Comparte:
Exporta:
Consulta las estadísticas

Los ítems del Repositorio están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.