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http://hdl.handle.net/10609/147793
Title: | APPRAISE-RS: Automated, updated, participatory, and personalized treatment recommender systems based on GRADE methodology |
Author: | López, Beatriz Raya, Oscar Baykova, Marina Sáez Zafra, Marc Rigau, David Cunill, Ruth Mayoral, Sacramento Carrion, Carme Serrano, Domènec Castells, Xavier |
Others: | Universitat de Girona CIBER Epidemiologıay Salud Publica (CIBERESP) Parc Sanitari Sant Joan de Déu Institut Català de la Salut Universitat Oberta de Catalunya. Estudis de Ciències de la Salut |
Citation: | López, B., Raya, O., Baykova, E., Saez, M., Rigau, D., Cunill, R., Mayoral, S., Carrión, C., Serrano, D. & Castells, X. (2023). APPRAISE-RS: Automated, updated, participatory, and personalized treatment recommender systems based on GRADE methodology. Heliyon, 9(2), 1-16. doi: 10.1016/j.heliyon.2023.e13074 |
Abstract: | Purpose Clinical practice guidelines (CPGs) have become fundamental tools for evidence-based medicine (EBM). However, CPG suffer from several limitations, including obsolescence, lack of applicability to many patients, and limited patient participation. This paper presents APPRAISE-RS, which is a methodology that we developed to overcome these limitations by automating, extending, and iterating the methodology that is most commonly used for building CPGs: the GRADE methodology. Method APPRAISE-RS relies on updated information from clinical studies and adapts and automates the GRADE methodology to generate treatment recommendations. APPRAISE-RS provides personalized recommendations because they are based on the patient's individual characteristics. Moreover, both patients and clinicians express their personal preferences for treatment outcomes which are considered when making the recommendation (participatory). Rule-based system approaches are used to manage heuristic knowledge. Results APPRAISE-RS has been implemented for attention deficit hyperactivity disorder (ADHD) and tested experimentally on 28 simulated patients. The resulting recommender system (APPRAISE-RS/TDApp) shows a higher degree of treatment personalization and patient participation than CPGs, while recommending the most frequent interventions in the largest body of evidence in the literature (EBM). Moreover, a comparison of the results with four blinded psychiatrist prescriptions supports the validation of the proposal. Conclusions APPRAISE-RS is a valid methodology to build recommender systems that manage updated, personalized and participatory recommendations, which, in the case of ADHD includes at least one intervention that is identical or very similar to other drugs prescribed by psychiatrists. |
Keywords: | treatment recommender systems evidence-based medicine meta-analysis attention deficit hyperactivity disorder |
DOI: | https://doi.org/10.1016/j.heliyon.2023.e13074 |
Document type: | info:eu-repo/semantics/article |
Version: | info:eu-repo/semantics/publishedVersion |
Issue Date: | 24-Jan-2023 |
Publication license: | https://creativecommons.org/licenses/by-nc-nd/4.0/ |
Appears in Collections: | Articles Articles cientÍfics |
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