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Title: Low levels of CIITA and high levels of SOCS1 predict COVID-19 disease severity in children and adults
Author: Argüello González, Guillermo
Bonet Carne, Elisenda
Girona Alarcon, Mònica
Esteve Sole, Ana
Bobillo Perez, Sara
Burgos Artizzu, Xavier Paolo
Mensa Vilaró, Anna
Codina, Anna
Hernández Garcia, María
Jou, Cristina
Alsina, Laia
Jordan, Iolanda
Others: Universitat Oberta de Catalunya
Universitat de Barcelona
Institut de Recerca Sant Joan de Déu
Keywords: COVID-19
Issue Date: 21-Jan-2022
Publisher: iScience
Citation: Girona Alarcon, M et al. (2022). Low levels of CIITA and high levels of SOCS1 predict COVID-19 disease severity in children and adults. iScience (25), j.isci.2021.103595
Published in: 25;1
Project identifier: info:eu-repo/grantAgreement/ES/PI18/00223
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Abstract: It is unclear why COVID-19 ranges from asymptomatic to severe. When SARS-CoV-2 is detected, interferon (IFN) response is activated. When it is insufficient or delayed, it might lead to overproduction of cytokines and severe COVID-19. The aim was to compare cytokine and IFN patterns in children and adults with differing severity with SARS-CoV-2.It was a prospective, observational study, including 84 patients. Patients with moderate/severe disease had higher cytokines' values than patients with mild disease (p< 0.001).Two IFN genes were selected to build a decision tree for severity classification: SOCS1 (representative of the rest of the IFN genes) and CIITA (inverse correlation). Low values of CIITA and high values of SOCS1 indicated severe disease. This method correctly classified 33/38(86.8%) of children and 27/34 (79.4%) of adults. To conclude, patients with severe disease had an elevated cytokine pattern, which correlated with the IFN response, with low CIITA and high SOCS1 values.
Language: English
ISSN: 2589-0042MIAR
Appears in Collections:Articles cientÍfics

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