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Títol: In vivo imaging of chronic active lesions in multiple sclerosis
Autoria: Calvi, Alberto  
Haider, Lukas  
Prados Carrasco, Ferran  
Chard, Declan  
Barkhof, Frederik  
Altres: University College London (UCL)
Universidad Oberta de Catalunya (UOC)
Citació: Calvi, A., Haider, L., Prados, F., Tur, C., Chard, D. T. & Barkhof, F. (2022). In vivo imaging of chronic active lesions in multiple sclerosis. Multiple Sclerosis Journal, 28(5), 683-690. doi: 10.1177/1352458520958589
Resum: New clinical activity in multiple sclerosis (MS) is often accompanied by acute inflammation which subsides. However, there is growing evidence that a substantial proportion of lesions remain active well beyond the acute phase. Chronic active lesions are most frequently found in progressive MS and are characterised by a border of inflammation associated with iron-enriched cells, leading to ongoing tissue injury. Identifying imaging markers for chronic active lesions in vivo are thus a major research goal. We reviewed the literature on imaging of chronic active lesion in MS, focussing on ‘slowly expanding lesions’ (SELs), detected by volumetric longitudinal magnetic resonance imaging (MRI) and ‘rim-positive’ lesions, identified by susceptibility iron-sensitive MRI. Both SELs and rim-positive lesions have been found to be prognostically relevant to future disability. Little is known about the co-occurrence of rims around SELs and their inter-relationship with other emerging techniques such as dynamic contrast enhancement (DCE) and positron emission tomography (PET).
Paraules clau: esclerosi múltiple
lesions actives cròniques
imatges per resonancia magnètica
tomografia per emisió de positrons
tomografía por emisión de positrones
DOI: https://doi.org/10.1177/1352458520958589
Tipus de document: info:eu-repo/semantics/review
Versió del document: info:eu-repo/semantics/publishedVersion
Data de publicació: 1-abr-2022
Llicència de publicació: http://creativecommons.org/licenses/by/4.0  
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