Por favor, use este identificador para citar o enlazar este ítem:
http://hdl.handle.net/10609/146842
Título : | In vivo imaging of chronic active lesions in multiple sclerosis |
Autoría: | Calvi, Alberto Haider, Lukas Prados Carrasco, Ferran TUR, CARMEN Chard, Declan Barkhof, Frederik |
Otros: | University College London (UCL) Universidad Oberta de Catalunya (UOC) |
Citación : | Calvi, A., Haider, L., Prados, F., Tur, C., Chard, D. T. & Barkhof, F. (2022). In vivo imaging of chronic active lesions in multiple sclerosis. Multiple Sclerosis Journal, 28(5), 683-690. doi: 10.1177/1352458520958589 |
Resumen : | New clinical activity in multiple sclerosis (MS) is often accompanied by acute inflammation which subsides. However, there is growing evidence that a substantial proportion of lesions remain active well beyond the acute phase. Chronic active lesions are most frequently found in progressive MS and are characterised by a border of inflammation associated with iron-enriched cells, leading to ongoing tissue injury. Identifying imaging markers for chronic active lesions in vivo are thus a major research goal. We reviewed the literature on imaging of chronic active lesion in MS, focussing on ‘slowly expanding lesions’ (SELs), detected by volumetric longitudinal magnetic resonance imaging (MRI) and ‘rim-positive’ lesions, identified by susceptibility iron-sensitive MRI. Both SELs and rim-positive lesions have been found to be prognostically relevant to future disability. Little is known about the co-occurrence of rims around SELs and their inter-relationship with other emerging techniques such as dynamic contrast enhancement (DCE) and positron emission tomography (PET). |
Palabras clave : | esclerosis múltiple lesiones activas crónicas imagenes por resonancia magnética |
DOI: | https://doi.org/10.1177/1352458520958589 |
Tipo de documento: | info:eu-repo/semantics/review |
Versión del documento: | info:eu-repo/semantics/publishedVersion |
Fecha de publicación : | 1-abr-2022 |
Licencia de publicación: | http://creativecommons.org/licenses/by/4.0 |
Aparece en las colecciones: | Articles Articles cientÍfics |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
In vivo imaging of chronic active lesions in multiple sclerosis.pdf | 349,24 kB | Adobe PDF | Visualizar/Abrir |
Comparte:
Los ítems del Repositorio están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.